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Revisit gut microbiota and its impact on human health and disease

Reducing intestinal barrier permeability attenuates arthritis Since our results suggested that increased zonulin levels along with impaired intestinal permeability for lactulose and FITC-Dextran (FD4) are preceding the onset of murine and human arthritis, we sought an intervention that strengthens the intestinal barrier and may disrupt the transition from autoimmunity to inflammation and thereby inhibit the onset of arthritis

In an open-label phase 1 clinical trial, 17 male patients with ED after radical prostatectomy were insensitive to PDE5I and ICI

To recapitulate this model ex vivo, we treated slices with 1 mM CPZ and 15 ng/mL rapamycin continuously for 1 week, in an attempt to sustain CPZ-induced demyelination in the corpus callosum