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We treated hepatocytes with auranofin, which inhibits redox-active selenoproteins, including thioredoxin reductases and, at the dose used here, glutathione peroxidases 1, 2, 3, 4, and 6 (Chaudiere and Tappel, 1984, Roberts and Shaw, 1998, Scarbrough et al., 2012)

Ann N Y Acad Sci 939:162178 Calabrese V, Ravagna A, Colombrita C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella AM (2005) Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2

Moreover, the pathological mechanisms of these endothelial injuries seem to be attributed to disorders of the NO/cGMP pathway, abnormal endothelium-derived vasoactive factors, oxidative stress, etc

Novo Nordisk filed an NDA for the CagriSema combination in December 2025, with an FDA decision anticipated in late 2026