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On one hand, toxin-based models tackle the investigation of oxidative stress and selective DA neuronal vulnerability, making them optimal for studying neuroprotective approaches

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NcRNAs contribute to cisplatin resistance in ovarian cancer through multidimensional ways: MiRNAs regulate resistance by targeting apoptotic molecules [35,36,37,38,39] and signaling pathway nodes

The tradeoff is that higher doses require substantial volumes, and a full 2.4mg maintenance dose would require nearly 1.44ml, which exceeds the capacity of a standard 1ml insulin syringe