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The % release has reduced to 59% in ex-vivo from 79 % in-vitro

Additionally, markers of lipid peroxidation, such as MDA and 4-hydroxynonenal (4-HNE), showed no change

This observation is additionally supported by our finding of Alk3 and insulin co-localization upon THR-123 treatment, an occurrence that was specifically ruled out in other regeneration models that propose an islet origin for the -cells that line ducts 21

Figure 2 4.1 Strategies targeting the glycolytic pathway 4.1.1 Inhibitors of key glycolytic enzymes Targeting core enzymes of the glycolytic pathway is a direct strategy to intervene in this metabolic axis