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The activities of manganese superoxide dismutase and glutathione-S-transferase, which detoxify superoxide and other electrophilic substances, respectively, are also inhibited by nitration (203, 346)

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DiNicolantonio, PharmD, Wegmans Pharmacy, Ithaca, NY, observes, Although therapies for acute coronary syndrome (ACS), including percutaneous coronary intervention, dual antiplatelet therapy, b-blockers (BBs), statins, angiotensin-converting enzyme inhibitors (ACEIs), omega-3 fatty acids, and cardiac rehabilitation, have markedly improved clinical outcomes, adverse cardiovascular (CV) events still occur too frequently after ACS

Acknowledgements We thank the Research Support Center for Human Disease Models, Graduate School of Medicine, Kyushu University, for technical assistance