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This differential sensitivity, where cytotoxic T cells (Teffs) are exhausted and immunosuppressive cells like regulatory T cells (Tregs) thrive, is a fundamental mechanism of immune evasion

Importantly, no serious adverse events were observed among the participants during the study period, suggesting that 1250 mg/d oral NMN is safe and well-tolerated in healthy adults for at least 4 weeks [60]

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These salvage treatment options have a narrow therapeutic index in comparison to first- and second-line therapeutic agents and need close monitoring for adverse effects and therapeutic levels (Table 5)