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Exosomes derived from mesenchymal stem cells

Activated M1 macrophages engulf and destroy microbes, eliminate damaged cells (e.g., tumor cells and apoptotic cells), present antigens to T cells for increasing the adaptive immune response, and produce high levels of pro-inflammatory cytokines (e.g., IL-1, IL-6, and IL-23), Reactive Oxygen Species (ROS), and Nitric Oxide (NO), as well as activate other immune and non-immune cells

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With your thumb and 3rd finger holding the middle of the syringe (similar to holding a pencil or pen but with different fingers) and your index finger on the plunger of the syringe, quickly insert the needle AT A 10-30 DEGREE ANGLE (this way it is impossible to go too deep) until it stops at the hub of the needle/syringe