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These changes make care safer, more efficient, and more comfortable

For example, in neonatal and adult heart tissues, fibroblasts arise from endogenous cell populations via epithelial to mesenchymal transition (EMT) and from bone marrow derived cells (Visconti et al., 2006)

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More importantly, PKM2 can translocate into the nucleus, where it regulates the transcription of metabolic genes such as HIF-1, LDHA, and GLUT1, thereby enhancing glycolysis, suppressing OXPHOS, and establishing a metabolic firewall against therapeutic stress [97]