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Further research is needed to clarify the potential pathological connection between NB and the symptoms or emergence of IC/PBS

doi: 10.1089/jir.2012.0063 225 CoombesJLSiddiquiKRRArancibia-CrcamoCVHallJSunC-MBelkaidYet al

When RLS is unrelated to other medical conditions, it is called primary RLS

Anecdotally, when CVS and migraines coexist, both have been observed to respond to TADs, but at different doses, obliging the physician to increase the amount of the drug, even when symptoms of one of the disorders have disappeared