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This section delineates the IR-mitochondria axis as a central mechanistic framework for understanding perioperative immune dysregulation and its downstream consequences for multi-organ protection

Consider increased clinical or laboratory monitoring for medications that have a narrow therapeutic index or that require clinical monitoring Use in Specific Populations Pregnancy: Available data with semaglutide use in pregnant women are not sufficient to determine a drug associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes

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In addition, it has been reported that TRPA1 is upregulated by NRF2 and enhances tolerance to oxidative stress in tumor cells (Takahashi et al