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Three phenomena leading to oxidative stress in the brain, and implicated in neurodegenerative diseases, include inhibition of mitochondrial metabolism, neuronal excitotoxicity, and neuroinflammation [35]

Mitophagy as a central component of cardiac mitochondrial quality control Parallel to macroautophagy, mitophagy plays a particularly critical role in safeguarding mitochondrial quality control (MQC), especially given the extreme energetic demands of the heart

In other studies, zinc deficiency exacerbates hepatic lipid metabolism, while Zn supplementation increases hepatocyte activity and improves lipid metabolism in the liver [77, 78]

doi: 10.1186/s12974-022-02492-0 208 XiaoWSuJGaoXYangHWengRNiWet al