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PMC 5592688

B12 deficiency has a small number of common causes worth recognising before reaching for an ampoule

At the molecular mechanism level, critical questions remain unanswered: the specific molecular interaction networks underlying NTFs-mediated mitochondrial regulation (e.g., the full spectrum of PGC-1 post-translational modifications, the selective recognition mechanism of NTFs-induced mitophagy) have not been fully elucidated, and heterogeneous responses at the single-cell level require further investigation