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At baseline (Week 26) for the two groups combined, mean age was 48 years

The most reproducible single mechanism is non-canonical activation of the VEGFR2-Akt-eNOS axis : Hsieh and colleagues showed that BPC-157 induces VEGFR2 internalization and downstream signaling in endothelial cells in the absence of VEGF, supporting capillary outgrowth in the wound bed

While the exact causes remain complex and not fully understood, it is generally believed that a combination of genetic and environmental factors contributes to its development