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Injectable administration likely achieves higher blood concentrations, though comparative human data does not exist

Urgent symptoms such as sudden confusion, balance problems, or rapidly worsening numbness may indicate Wernicke's encephalopathy and require immediate emergency assessment

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There were 80 patients who attained a pre-specified level of symptom improvement and who entered the double-blind phase, in which they were randomized in equal proportions to receive NEXIUM or placebo for the next four weeks