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doi:10.1002/smtd.202400902 195

Book Chapters Zeng Z, Konopleva M, Andreeff M

Beyond their established effects on DNA methylation, SeNPs have been shown to modulate histone methylation by influencing the expression of specific histone methyltransferases (HMTs) such as EZH2, SETD7, and SUV39H2/KMT1B, and by altering the S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio through the transsulfuration pathway

Whereas many of the minor events may be considered as mere passenger mutations, some are plural minor contributing events as illustrated by the many low penetrance polymorphisms linked to several types of cancer [11]