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[318 319] Through volume standardization we allow comparisons across hospitals of all sizes, while accounting for potential variations associated with patient volume, such that large volume EDs will be compared to large volume EDs, while medium and smaller volume EDs will likewise be compared to EDs of similar size

In CY 2025 rulemaking, we conducted studies to calculate HCPCS geometric mean costs for the cardiac CT codes based on a simulation that assumed that differing numbers of HOPDs (specifically 25 percent, 50 percent, and 75 percent of the total number of HOPDs billing for these services) would have assigned these services to the cardiology revenue code (048X) and cardiology cost center (03410)

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Notably, it can potentially affect the efficacy or side-effect profile of drugs such as nitroglycerin, nitrates, and some chemotherapy agents