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Description

Berberine, a single bioactive compound derived from several Chinese medicinal herbs, increased hippocampal 5-HT, NE, DA, and BDNF levels in CUMS rats while modulating SCFA metabolism via alterations in Firmicutes, Bacteroidetes, and Lachnospiraceae (Huang M

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Regulatory T cells and clinical application

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This is based on its 6 to 8 day half-life and the pharmacological principle that 4 to 5 half-lives are required for near-complete elimination

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