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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Junyi L., Yueyang W., Bin L., Xiaohong D., Wenhui C., Ning Z., Hong Z

Severe gastroparesis or other serious GI motility disorders make tirzepatide problematic

The most common side effects are extremely mild and infrequent, primarily involving occasional skin irritation, mild redness, or transient tingling sensation in a small percentage of users, typically resolving without intervention and not requiring discontinuation

[1] A 2019 review in Clinical Epigenetics confirmed that both food-derived and synthetic peptides directly alter DNA methylation and histone activity by interacting with the enzymes that control them