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Molecular Pharmacology., 96 (2), 219232

1 2 Siegfried Czapski, Theorie der optischen Instrumente, nach Abbe, Breslau: Trewendt, 1893

39 Due to the potentially ideal clinical outcomes of silica-based nanocarriers, the pharmacokinetics, safety, and metabolic profile of a hybrid core-shell silica NP (named Cornell dots, C dots) with a diameter of 6 nm functionalized with 124 I, targeting peptide cyclo-(Arg-Gly-Asp-Tyr), and Cy5 ( 124 I-cRGDYPEGC dots) is first conducted in humans using PET imaging and clinical tracer at clinical trials in 2014 (NCT01266096)

Peptides were extracted from the gel matrix using 40% ACN containing 0.1% formic acid