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Presumably, the solution was stored in unopened containers (as opposed to multi-dose vials from which any doses had been previously extracted, although this was not explicitly stated

11 Humans risk overexposure from environmental concentrations that occur naturally (eg, arsenic-rich mineral deposits) or human activities (eg, lead or mercury release as a result of industrial pollution)

To circumvent these issues, ionizable lipids (amphiphilicpositively charged at low pH and neutral at pH 7) have been developed as illustrated in Figure 5 [95]