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Briefly, cellular pellets (10 g) were mixed with 30 l 5% metaphosphoric acid, and then frozen and thawed twice using liquid nitrogen and 37 C water

It has been suggested that the stronger the skin sensitizer the larger the tendency is to modify several nucleophilic sites within the same protein, as this leads to generation of a larger number of different antigens

Given the complicated pathogenesis of acne, we propose that probiotic-based multi-target therapies hold significant potential for effective acne treatment

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