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Y.et al (2018)

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Although it is clear that impaired ATP production, mtDNA damage, and impaired inner and outer membrane transport are central events in mitochondrial dysfunction, the specific mechanisms of mitochondrial dysfunction remain unestablished ( Figure 1 3 Mechanisms of mitochondrial dysfunction in RA 3.1 mtDNA mutations Human mtDNA is generally maternally inherited with a high copy number, and a typical eukaryotic cell contains hundreds to thousands of individual mtDNA molecules