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Ferrous iron can catalyze the formation of hydroxyl radicals through the Fenton reaction, which initiates LPO [78]

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Alteration of iron metabolism is the preeminent defect caused by GSH depletion When grown in medium devoid of GSH, yeast cells lacking GSH1 ( gsh1 ) become growth arrested after 810 divisions by nearcomplete GSH depletion (Spector et al , 2001)

Several compounds have been identified or characterized as SLC7A11 inhibitors, including erastin, imidazole ketone erastin (IKE), sulfasalazine, sorafenib, and HG106 (Feng and Stockwell, 2018