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LOOPER: A molecular mechanics-based algorithm for protein loop prediction

Mol Immunol (2020) 128:17587

Subsequent assessments of mitochondrial function demonstrated that PX-478 treatment severely impaired mitochondrial activity, as evidenced by decreased ATP-linked OCR, reduced MMP, and lower ATP levels (Fig

In addition, Nrf2 induces the expression of SLC7A11, which promotes cystine uptake and supports GSH production, thereby reinforcing the cellular defense against ferroptosis ( Nrf2 also plays a role in iron metabolism, which is closely linked to ferroptotic susceptibility