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Intranasal delivery, though less studied with Dihexa, would theoretically provide direct CNS access with minimal systemic exposure, potentially requiring the least frequent administration to maintain effective brain tissue concentrations

References Walker RF, et al

Simental-Mendia 2014)

In addition, reduced concentrations of MACs in the diet has been associated with increasing the effect antibiotic administration has on disrupting microbial community composition in the gut (Ng et al