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Future breakthroughs can rely on three aspects: precise identification of IDO1-dependent AML subpopulations (such as single-cell sequencing to analyze IDO1 + cell clusters), development of novel metabolic intervention strategies (such as regulating the availability of tryptophan through gut microbiota), and exploration of time-dependent dosing regimens (such as first targeting leukemia cells and then reversing immunosuppression)

10.1016/j.ijbiomac.2022.04.192 263 ZhaB

Int J Phys Sci 8:840847 Jain M, Gadre RP (2004) Inhibition of 5-amino levulinic acid dehydratase activity by arsenic in excised etiolated maize leaf segments during greening

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