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Research indicates that the reduction in serum B12 levels typically becomes clinically significant after several years of continuous metformin therapy

Common findings include reduced microbial diversity, depletion of short-chain fatty acid (SCFA)-producing genera, and enrichment of pro-inflammatory taxa

The beauty lies in its consistent, cumulative effecteach use builds upon the last, creating visible improvements over time

(Laske et al., 2007), AD patients have lower CSF levels of BDNF than healthy controls due to progressive brain neurodegeneration, which is also present in patients with normal-pressure hydrocephalus