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We first confirmed that the addition of alkyne handles to SCLA1-4 did not ablate senolytic activity (Extended Data Fig

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Interestingly, a lack of estrogen can also cause similar symptoms

This is a consequence of senescent cells being primed for apoptosis and upregulating antiapoptotic mechanisms to prevent intrinsic 24 and extrinsic 26 apoptosis, which makes them vulnerable to the inhibition of these protective mechanisms