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This is considered to exhibit a two-fold action

87 NaghashpourM.JafariradS.AmaniR.SarkakiA.SaedisomeoliaA

In yet another embodiment, the one or more agents that down-regulate the copy number, amount, and/or activity of at least one target listed in table 1 and/or table 2 is a small molecule inhibitor, a CRISPR guide RNA (grna), an RNA interfering agent, an antisense oligonucleotide, a single-stranded nucleic acid, a double-stranded nucleic acid, an aptamer, a ribozyme, a dnase, a peptide, a peptidomimetic, an antibody, an intracellular antibody, or a cell

However, while younger patients with CKD typically experience progressive loss of kidney function, 30% of patients over 65 years of age with CKD have stable disease (27)