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Most recently another controlled trial of prasinezumab (PADOVA), which had enrolled subjects with more advanced disease compared to the initial trial and randomised subjects to 4-weekly iv injections of 1500 mg prasinezumab or placebo for at least 76 weeks, used time to 5-point worsening on MDS-UPDRS part III scores as primary outcome measure

This speculation is consistent with a recent report illustrating that precursor autoprocessing is context-dependent and its outcomes can be modulated by sequences outside the PR coding region 34

Sci Total Environ 547:6077

Having delineated the core barriers that lead to the numerical paucity of tumor-specific T cells in the TME, we now turn to a contrasting layer of complexity: the numerical dominance of tumor-irrelevant bystander T cells