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Hesperidin (Matias et al., 2017), rutin (El-Sayed el et al., 2008), and rhamno (Omar et al., 2017) can reduce the amount of free Ca 2+ located between brain cells when fighting against neurogenic excitotoxicity and can attenuate the decrease of the mitochondrial membrane potential and increase caspase-3 activity (Lutz et al., 2015)

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John MV, Schneeweiss-Gleixner M, Eisenwort G, Peter B, Berger D, Stefanzl G, Konopleva M, Andreeff M , Isalm W, Schwaab J, Reiter A, Sperr WR, Arock M, Valent P, Gleixner K

The interplay between inflammatory cells, mitochondrial dysfunction, and ROS production culminates in epithelial damage, a common feature portraying conditions like asthma [1316]