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The insertion of insulators into the vector was also shown to decrease vector titer [179], [181]

Beyond this global shift, aerobic glycolysis remains active in differentiating neurons and plays a crucial role in supporting localized energetic and biosynthetic demands [3, 4]

Administration of Que at a concentration of 1000 mg/day or more for several months showed no adverse effects in serum electrolytes, renal and hepatic function, blood parameters, or hematology (Ferry et al., 1996)