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Elevated intracellular Ca 2+ concentrations subsequently augment signaling pathways involving protein kinase C (PKC), calcineurin, and Ca 2+ /calmodulin-dependent protein kinase II (CaMKII), which result in alterations in gene expression relevant to the pathology of cardiac diseases[125]

Additionally, gut-derived phenolic compounds reduce inflammation by inhibiting NF-B-dependent cytokine signaling

Cell pellets were blocked in 1% BSA and stained with anti CD40APC (Miltenyi Biotec, 130-116-111) to assess surface CD40 expression by flow cytometry (NovoCyte)