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Bioinformatic studies have shown that genes associated with necroptosis are altered in the brains of PD patients compared to control subjects, suggesting an increased susceptibility to necrotic cell death in these patients (Lei et al., 2023)

Therefore, researchers speculated that DCs may also play a regulatory role in AILI, and proved not only the immunophenotype but also the secretion of inflammatory mediators in DCs change after APAP stimulation, including higher expression of MHC II and Toll-like receptors, and producing more IL-6, TNF-, etc

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They also balance estrogen and androgen activity