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Current experiments rely on rotenone or MPTP models, which do not replicate environmental exposure patterns or genetic heterogeneity in sporadic PD, and lack evaluation of bloodbrain barrier penetration and lesion-targeting delivery

Functional synthetic probes for selective targeting and multi-analyte detection and imaging

Hamada et al

In dextran sulphate sodium (DSS)-induced colitis mice, the most commonly used preclinical IBD model, injected MOTS-c significantly reduced colon shortening and histological damage, lowered pro-inflammatory cytokines and plasma myeloperoxidase, and curbed macrophage and neutrophil activity