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Acknowledgements Support was provided by NSERC Canada (RGPIN-2019-06050 and RGPAS-2019-00051 to R.J.L., RGPIN-2017-06167 to B.H.R., CGS-D fellowship to M.G.J.D., PGS-D fellowship to B.A.M., PGS-D fellowship to C.J.C.C.), the Canadian Foundation for Innovation (IOF 32691 to R.J.L., JELF 36848 to B.H.R.), the Province of Alberta (AGES fellowship to O.B., AGES fellowship to M.G.J.D., AGES fellowship to C.J.C.C.), the Province of Ontario (ER17-13-119 to B.H.R.), and the University of Ottawa Heart Institute (Endowed Fellowship to M.M.)