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Moreover, the induction of autophagy can limit tumor growth, while the inhibition of autophagy can, at times, promote apoptotic death in cancer cells 28

In a subset of liver fluke-positive CCAs (cluster 1), global hypermethylation was linked to ARID1A and BRCA1/2 mutations and increased gene promoter alterations related to histone 3 lysine 27 trimethylation, predicted to affect transcription factor binding and, consequently, gene expression 74