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doi: 10.1038/s41591-022-01790-7 6 YangSLiYZhouLWangXLiuLWuM

In addition to xenobiotic detoxification through glutathione conjugation, GSTs also play a key role in the synthesis and metabolism of endogenous compounds, redox homeostasis and cellular signalling 1,2

Immune-specific Because immune cells have high metabolic activity and high rates of proliferation, they require folate to form new immune cells and mount a proper immune response