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On the other hand, acquired resistance emerges during treatment and is typically attributed to the development of drug-resistant cancer cell populations that often contain secondary genetic alterations, ultimately leading to therapy failure

Ann N Y Acad Sci (1990) 604:52844.10.1111/j.1749-6632.1990.tb32018.x 3 StjarneLBrundinJ

These notably include Arabidopsis mutants deficient in the major leaf form of catalase (CAT2), in which conditionally increased H 2 O 2 availability through photorespiration drives reproducible changes in GSSG:GSH (Mhamdi et al., cat2 gr1 double mutants lacking both enzymes (Figure 3)

1,2 People with fibromyalgia also experience multiple other symptoms, particularly fatigue, sleep disturbance, cognitive challenges (sometimes called fibro fog), and frequently a range of other concerns such as tender points, muscle stiffness, other types of pain, and mood disorders