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Genetic Analysis of the TSPO Gene A single nucleotide polymorphism (SNP) in the TSPO gene causes differential radioligand binding In vitro studies demonstrate that PK11195 and second-generation TSPO-binding radioligands have different binding sites on the TSPO protein (59)

No ramp-up

This pattern could be attributed to the interplay between APOE E4 and Hcy, leading to heightened oxidative stress and DNA damage