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The inclusion criteria were as follows: (1) age between 3 months and 20 years, (2) diagnosed with refractory epilepsy, having persistent seizures even after administration of two or more ASMs, (3) history of seizures within 2 weeks before the study, (4) baseline seizure frequency of more than 2 times per month Patients with a broad spectrum of seizure frequency was included to reflect the clinical heterogeneity of refractory epilepsy

Gene expression studies have demonstrated that MT genes are differentially regulated in response to a variety of HM stresses (Qu et al., 2024)

Adv Sci (Weinh) e2411380 Deng Y, Zeng L, Liu H, Zuo A, Zhou J, Yang Y, You Y et al (2024b) Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1

Littler et al., 2008)