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Nucleosome binding was assessed by an EMSA using a 601 mononucleosome with a 30 bp DNA extension on both ends

Overall, 13 portal tracts were analyzed from each liver, and a total of 10 tracts from NAC treated mice, and 8 tracts from untreated mice were analyzed

In both AID patients and corresponding animal models, the expansion and accumulation of MDSCs protect host tissues from damage caused by excessive T cell responses by inhibiting T cell activation and immune reactions (102, 119), This further indicates that MDSCs may exert a detrimental impact on immune responses by modulating the functions of CD4 + and CD8 + T cells, thereby contributing to the pathological processes of AIDs

Their levels would not be expected to decrease with pyridoxine therapy