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Patients can present with the following signs & symptoms: CNS (areflexia, asthenia, ataxia, blurred vision, disorientation, dizziness, drowsiness, hyporeflexia, slurred speedh, somnolence, staggering, tiredness, coma) Cardiovascular (initial hypertension, followed by long-lasting hypotension , bradycardia , premature ventricular beats) the peripheral actions of xylazine cause an initial increase in blood pressure, followed by central effects that result in a long-lasting hypotensive effect, accompanied by bradycardia and reduced cardiac output (Hoffman et al, 2001)

doi: 10.1152/ajpheart.00471.2010

Dalton Trans ., 18831888, (1997)

In 2023, the Mainstreaming Addiction Treatment Act (MAT Act) eliminated the need for a special waiver to treat patients with OUD