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Furthermore, M2 macrophages have been reported to secrete vascular endothelial growth factor (VEGF), TGF-, and arginine, promoting the synthesis of collagen and proteoglycans, which enhances cartilage regeneration ( In summary, macrophages are critical for promoting OA progression in the early stages, but their polarization toward the M2 phenotype in later stages can help mitigate OA or repair damaged tissues

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JS-G, VM, ER, IL, and LF contributed to the design of the schemes and wrote the manuscript