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Description

Loss of NCOA4 substantially decreases ferroptosis susceptibility, reducing cell death by approximately 62% (Savo and Dill, 2019)

In the absence of reduced glutathione (e.g., due to G6PD deficiency), RBCs become susceptible to oxidative stress that can damage erythrocyte membranes, resulting in intravascular and extravascular hemolysis

Even so, detection still depends heavily on the type of test being used

As mentioned above, the PLs peroxidation of membrane can lead to the leakage of cellular contents, and the release of DAMPs will further initiate other cell death ways