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reported that female rats exposed to Hcy developed a PCOS-like reproductive-endocrinal phenotype associated with lipid metabolism disorders without involvement of other modalities used for PCOS modeling

Moreover, patients with PD were reported to have lower peripheral blood levels of t--Syn, which was inversely linked to their motor impairments (Daniele et al., 2018)

Current preclinical and clinical data that supports the effectiveness of polyphenols in reducing the advancement of diseases, boosting cognitive abilities, and promoting overall brain health ( 2 Polyphenols pharmacological function to protect neuroinflammation and neurodegenerative diseases Neuroinflammation is a pathological process that involves the activation of glial cells and the subsequent production of pro-inflammatory cytokines, resulting in neuronal damage and impaired functionality (Figure 2) (Table 1 is a representation of the pharmacological function of polyphenols under different neurodegenerative diseases

Another investigation explored the use of ultrasonic treatment with 70% ethanol at 80% power and 60C for 20 min to extract flavonoids