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Specifically, a high-fat and high-sugar diet increased the -amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid to N-methyl-D-aspartic acid receptor current ratio in medium spiny neurons and prolonged spontaneous glutamate-mediated currents, increased DA release and slower DA reuptake in the striatum, and reduced MOR-mediated synaptic plasticity (73)

doi: 10.5603/CJ.a2020.0145

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Like Fer-1, Liproxstatin-1 (Lip-1) and Liproxstatin-2 (Lip-2) are ferroptosis inhibitors identified through small molecule screening (Friedmann Angeli et al., 2014