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For Syn 1103 and Syn 1103 -104C constructs, eluted fractions were further purified using a HiTrap Heparin HP column (Cytiva, MA, USA), leveraging cation-exchange conditions due to their higher isoelectric point (pI ~9.5)

MGF is a splice variant of IGF1 (IGF1Ec) that is produced in muscle tissue after mechanical stress or damage, acting as a potent local repair factor

Continuing to bill M54.50 after a specic cause is documented is a compliance issue that appears frequently in payer audits

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