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Aldemir, M

Halalkhor, F

Abbreviations ACh: Acetylcholine AI: Atherogenic index Akt1: Protein kinase B ALA: Alpha-linolenic acid ALT: Alanine transaminase AMPK: Activation of 5 AMP-activated protein kinase AR: Androgen receptor ARE: Anti-oxidant response element AST: Aspartate transaminase BCAAs: Branched-chain amino acid CaMKK: Calmodulin-dependent protein kinase kinase COX-2: Cyclooxygenase-2 CRF: Cardiac risk factor CVD: Cardiovascular diseases ErbB2: Erb-b2 receptor tyrosine kinase 2 ET-1: Endothelin-1 FBG: Fasting of blood glucose FINS: Fasting serum insulin FST: Forced swimming test GLP1: Glucagon-like peptide 1 GLUT: Glucose transporter GSH: Glutathione GSK: Glycogen synthase kinase HbA1c: Hemoglobin A1C HDL: High-density lipoprotein cholesterol HOMA-IR: Homeostatic model of assessment of insulin resistance hs-CRP: Serum high-sensitive C reactive protein ICAM-1: Intercellulare adhesion molecule-1 IFN-: Interferon-gamma IL-6: Interleukin-6 iNOS: Inducible nitric oxide synthase IRS: Insulin receptor substrate ISI: Insulin sensitivity index IB: Inhibitors of NF-B LDL: Low-density lipoprotein cholesterol LKB1: Liver kinase B1 MDA: Malondialdehyde MMP: Matrix metalloproteinase MAMs: Mitochondria-associated endoplasmic reticulum membranes MT: Metallothionein NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NO: Nitric oxide Nrf2: Nuclear factor erythroid 2-related factor 2 OGTT: Oral glucose tolerance test OVX: Ovariectomized PBG: Post-prandial blood glucose PI3K: Phosphatidylinositol-3 kinase PGC-1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PPAR: Proliferator-activated receptor QUICKI: Quantitative insulin sensitivity check index ROCK: Rho-associated protein kinase SFN: Sulforaphane SOD: Superoxide dismutase STZ: Streptozotocin T2DM: Type 2 diabetes mellitus T1DM: Type 1 diabetes mellitus TAS: Total anti-oxidant status TC: Total cholesterol TG: Triglycerides TGF-1: Transforming growth factor-1 TNF-: Tumor necrosis factor- TPS: Tail pinch stressor VCAM-1: Vascular cell adhesion molecule-1 VEGF: Vascular endothelial growth factor VGSC: Voltage-gated Na + channel References Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y et al (2017) Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Therefore, an opportunity may present itself to ameliorate ARTHS by treatment increasing histone acetylation in individuals with a reduction in histone acetylation