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246 Antiretinitis activity The mutagenic alteration in the X-linked retinitis pigmentosa gene is linked to loss of vision in humans, and there is no treatment for this disease presently

[PubMed: 31036494] 102

Simply put, it is to insert cysteine residues at specific points of the antibody through genetic engineering, and then couple the hydroxyl group on the cysteine with the toxin to form a site-specific antibody-drug conjugate

Lack of Human Clinical Trials : No approved human clinical trials exist for BPC-157, and benefit or safety data are derived exclusively from animal models